在语义变体中改变神经血管合的初级渐进性失语症
Yanxin Zhang1, Chunxue Ji1,2, Yaping Meng1
1Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China.
Journal of Alzheimer's disease : JAD
|December 13, 2024
概括
神经血管合 (NVC) 在语义变体初级渐进性失言症 (svPPA) 中受损,影响认知和语言功能. 这种干扰与受影响大脑区域的脑血流和神经活动减少有关.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 医疗成像医学成像
背景情况:
- 语义变体初级渐进性失语症 (svPPA) 是一个关键的前叶退行现象型.
- 在svPPA中观察到的神经元活动和 perfusion 的变化表明神经血管合 (NVC) 的潜在破坏.
研究的目的:
- 研究svPPA患者的NVC变化.
- 在svPPA中将NVC变化与临床表现相关联.
主要方法:
- 19名svPPA患者和36名对照患者接受了多模式MRI (rs-fMRI,ASL) 和神经心理测试.
- 低频波动 (ALFF) 和脑血流 (CBF) 的幅度测量了神经活动和 perfusion.
- 评估了全球和区域的NVC. Voxel-wise CBF-ALFF相关性和CBF/ALFF比率. 评估了全球和区域的NVC.
主要成果:
- 与对照组相比,svPPA患者的时间区域的全球CBF-ALFF相关性下降,以及较低的区域CBF/ALFF比率.
- 在svPPA中,左叶的区域CBF/ALFF比率与命名和一般认知相关.
结论:
- 在svPPA中,神经血管合被破坏.
- 在svPPA中,NVC变化与认知和语言缺陷有关.
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