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土耳其多发性硬化症患者的抗JCV抗体指数血清转化,这些患者接受了纳塔利祖马布治疗

Edanur Şahin¹, Tuncay Gündüz¹, Ahmed Serkan Emekli¹

¹Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

|December 13, 2024

概括

在接受纳塔利祖马布治疗的多发性硬化症患者中,抗JCV抗体血清转化与吸烟,更高的BMI和35岁后开始治疗有关. 对这些人来说,警监测至关重要.

科学领域:

神经学神经学
免疫学免疫学免疫学
药理学药理学是指药理学的学科.

背景情况:

抗JCV抗体指数对于监测多发性硬化症 (MS) 患者的纳塔利祖马布治疗至关重要.
对抗JCV抗体的血清转化增加了渐进式多焦点白血脑病 (PML) 的风险.

研究的目的:

为了确定在接受纳塔利祖马布治疗的多发性硬化患者中抗JCV抗体血清转换的患病率.
为了确定与抗JCV抗体血清转化相关的风险因素.

主要方法:

卡普兰-梅尔生存分析被用来计算血清转换的中位时间和年率.
考克斯回归模型确定了与血清转化相关的共变量.
该研究包括96名多发性硬化患者,他们至少有一年暴露于纳塔利祖马布,并且在基线时具有负的抗JCV抗体.

主要成果:

29.2%的患者 (29/96) 在99个月的中位数随访期间经历了血清转化.
血清转换的中位数时间为8.3年,年率为6.1%.
在吸烟者,BMI>25 kg/m2的患者和35岁以上开始服用纳塔利祖马布的人群中观察到更高的血清转化率.

结论:

吸烟,BMI升高和35岁后开始服用纳塔利祖马布是抗JCV抗体血清转换的重要危险因素.
大多数血清转化发生在治疗的前三年内.
在接受纳塔利祖马布治疗的高风险多发性硬化症患者中,建议对抗JCV抗体进行密切监测.

关键词:

抗JCV抗体指数指数多发性硬化症是多发性硬化症.娜塔莉莎表示渐进性的多焦点白内障脑细胞病变.

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