高度质瘤中的循环生物标志物:当前的见解和未来的前景
Suchet Taori1,2, Ahmed Habib2, Samuel Adida1,2
1School of Medicine, University of Pittsburgh, Pennsylvania, PA, USA.
Journal of neuro-oncology
|December 13, 2024
概括
循环生物标志物为高度质瘤 (HGG) 诊断和监测提供了一种有希望的,最少侵入性的方法. 虽然在检测和标准化方面仍然存在挑战,但这些生物标志物具有个性化神经瘤学的潜力.
科学领域:
- 神经瘤学神经瘤学
- 分子诊断学 分子诊断
- 生物标志物发现发现
背景情况:
- 高度质瘤 (HGG) 是具有不良预后的侵袭性脑瘤.
- 组织病理学,目前的诊断标准,是侵入性的,可能会错过瘤异质性.
- 液体活检为HGG管理提供了一个不那么侵入性的替代方案.
研究的目的:
- 审查关于HGG循环生物标志物的文献.
- 评估各种生物标志物在HGG诊断,预后和治疗监测中的潜力.
- 突出神经瘤学对精密瘤学的影响.
主要方法:
- 对HGG的循环生物标志物的文献综述.
- 包括循环瘤细胞 (CTC),ctEV,ctDNA,ctmiRNA和瘤衍生的蛋白质.
- 分析当前的技术局限性和潜力.
主要成果:
- CTC提供实时数据,但由于数量较少,难以检测.
- 循环瘤衍生的细胞外囊泡 (ctEVs) 是可检测的,但缺乏特异性,需要标准化.
- 循环瘤衍生DNA (ctDNA) 水平与疾病阶段相关,但需要敏感的检测方法.
- 循环瘤衍生的miRNA (ctmiRNA) 和蛋白质显示出希望,但面临着稀释和特异性的挑战.
结论:
- 循环生物标志物在HGG管理中具有变革性的潜力.
- 这些生物标志物可以改善患者的治疗结果,并优化治疗策略.
- 需要进一步开发以克服目前在神经瘤学中广泛临床应用的局限性.
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