在调节癌细胞对帕克利塔克塞尔 (PTX) 治疗耐药性的LncRNAs
Ali G Alkhathami1, Harikumar Pallathadka2, Sejal Shah3
1Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia.
Medical oncology (Northwood, London, England)
|December 13, 2024
概括
长非编码RNAs (lncRNAs) 在各种癌症中促进了对帕克利塔塞尔 (PTX) 的耐药性. 了解lncRNA的作用为克服PTX耐药性和改善癌症治疗结果提供了新的治疗策略.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 帕克利塔塞尔 (PTX) 是许多癌症的基石化疗剂.
- 由于帕克利塔克塞尔耐药性的癌症复发仍然是一个重大的临床挑战.
- 已建立的抗性机制包括β-tubulin的改变,药物排泄和亡失调.
研究的目的:
- 审查当前对长非编码RNAs (lncRNAs) 在帕克利塔塞尔耐药性的理解.
- 阐明导致PTX耐药性的lncRNAs的特定作用和途径.
- 突出 lncRNAs 作为克服药物耐药性的潜在治疗点.
主要方法:
- 对调查lncRNAs和帕克利塔克塞尔耐药性的研究进行文献综述.
- 对 lncRNA介导的 PTX 耐药性背后的分子机制的分析.
- 对关键的lncRNA及其相关信号通路的数据的合成.
主要成果:
- 长非编码RNAs (lncRNAs) 越来越多地被认为与癌症进展有关.
- 特定的lncRNAs调节关键的细胞过程,赋予了帕克利塔塞尔耐药性.
- lncRNAs影响β-tubulin,药物排放和亡途径,影响PTX的疗效.
结论:
- lncRNAs在各种癌症类型中对帕克利塔塞尔耐药性的发展中发挥着关键作用.
- 针对特定的lncRNAs是一个有前途的策略,可以使瘤对帕克利塔塞尔重新敏感.
- 对lncRNA功能的进一步研究对于开发新型癌症疗法至关重要.
相关概念视频
lncRNA - Long Non-coding RNAs
8.5K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.5K
Treatment Resistant Cancers
3.3K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K
Drugs that Stabilize Microtubules
2.0K
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.0K
Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
mTOR Signaling and Cancer Progression
3.7K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.7K
Cancer Stem Cells and Tumor Maintenance
4.8K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
4.8K


