开发和体外调整含有empagliflozin的可溶性微针贴片,以增强通过皮肤输送
Aqib Javed1, Rai Muhammad Sarfraz2, Asif Mahmood3
1College of Pharmacy, University of Sargodha, Sargodha, Pakistan.
Naunyn-Schmiedeberg's archives of pharmacology
|December 13, 2024
概括
可溶性微针贴片提供一种无痛,有效的方式,为2型糖尿病提供empagliflozin. 这种创新的透皮药物递送系统增强了药物透和稳定性,从而改善了全身药物递送.
科学领域:
- 制药科学 制药科学
- 生物材料工程 生物材料工程
- 药物输送系统 药物输送系统
背景情况:
- 用于治疗2型糖尿病 (T2DM) 的口服恩帕格利弗洛辛面临着包括快速吸收和可变生物利用性在内的挑战.
- 透皮药物递送系统 (TDDS),特别是微针贴片 (MNP),为增强药物透提供了最少侵入性的替代方案.
- 可溶性微针贴片 (dMNPs) 是一种新的方法,可以克服传统药物给药途径的局限性.
研究的目的:
- 开发和描述可溶性微针贴片 (dMNPs) 以改善empagliflozin的全身输送.
- 评估dMNPs在T2DM管理中增强empagliflozin通过皮肤透和稳定性的潜力.
- 评估优化dMNP配方的机械性能,稳定性和生物相容性.
主要方法:
- 微针贴片是使用基于模具的溶剂造技术与聚烯和聚乙醇制成的.
- 综合性表征包括SEM,FTIR,DSC,TGA,PXRD,溶解,机械测试和皮肤刺激研究.
- 分析了体外释放动力学,以确定最佳的药物释放模型.
主要成果:
- 优化的dMNP配方 (MP6) 显示了统一的,金字塔形的针头,具有良好的热稳定性和晶体药物聚合物结构.
- MP6表现出优良的机械性能,有效的药物溶解,受控释放,并在皮肤刺激测试中证明了生物相容性.
- 试验室释放数据最适合于零顺序的动力模型,表明药物释放受控.
结论:
- 优化的dMNP是稳定的,生物相容的,机械坚固的,适合通过皮肤输送empagliflozin.
- 这种dMNP系统为治疗T2DM,改善药物的生物可用性和患者遵守提供了口服的有希望的替代方案.
- 可溶性微针技术增强了药物透和全身传递,为先进的透皮疗法铺平了道路.
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