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基于图像的肥胖测量与非小细胞肺癌代谢途径的改变有关

Akhil Goud Pachimatla¹, Kaylan Gee^1,2, Hua-Hsin Hsiao³

¹Department of Thoracic Surgery, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.

Annals of surgical oncology

|December 13, 2024

概括

肥胖程度影响非小细胞肺癌 (NSCLC) 基因表达. 基于图像的脂肪与改变的代谢途径相关,为NSCLC患者提供新的治疗点.

科学领域:

在瘤学瘤学.
代谢学代谢学代谢学
基因组学就是基因组学.

背景情况:

非小细胞肺癌 (NSCLC) 的肥胖悖论可能源于使用体重指数 (BMI) 来定义肥胖.
身体脂肪和肺癌进展之间的直接联系尚不清楚.
这项研究调查了图像衍生体脂测量如何与NSCLC中的瘤基因表达有关.

研究的目的:

探索基于图像的肥胖指标和NSCLC瘤中的基因表达特征之间的关联.
为了识别与脂肪相关的特定转录特征.
揭示连接身体脂肪和肺癌行为的潜在生物机制.

主要方法:

分析了143名NSCLC患者 (ORlEN联盟) 的RNA测序数据.
使用CT扫描和SliceOmatic软件量化了总脂肪面积 (TFA).
进行了差异基因表达和代谢途径丰富分析,比较高TFA和低TFA组.

主要成果:

鉴定出1154个差异表达的基因转录,影响正常生理和癌症生长途径.
在114个代谢途径中,58个在高TFA的个体中显著丰富.
基因组丰富分析揭示了与TFA相关的炎症,细胞信号和细胞呼吸的改变途径.

结论:

通过成像测量脂肪,显示与NSCLC瘤中的基因表达变化有显著的相关性.
与肥胖相关的改变生物过程,包括代谢脆弱性,被确定.
这些发现表明NSCLC治疗的潜在新疗法策略.

关键词:

以图像为基础的措施.肺癌是一种肺癌.代谢途径肥胖肥胖代谢途径

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Obesity

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