相关实验视频

Updated: Jul 26, 2026

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

Published on: August 2, 2017

与带哺乳相比,胎盘循环完整的复苏:一个随机临床试验

Simone Pratesi¹, Martina Ciarcià¹, Luca Boni²

¹Careggi University Hospital, Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Firenze, Italy.

JAMA network open

|December 13, 2024

概括

在复苏期间维持胎盘循环3分钟并没有改善早产新生儿与带挤奶相比的结果. 这项研究发现,死亡或主要疾病的综合结果没有显著差异.

科学领域:

新生儿复苏新生儿的复苏
围产儿医学围产儿医学
临床试验临床试验

背景情况:

在早产新生儿中延迟带紧 (60秒) 可以降低死亡率.
较长的绳索紧持续时间与呼吸支效应是未知的.
带挤奶是一种延迟紧的替代方案.

研究的目的:

为了比较完整的胎盘循环复苏 (180秒) 与早产新生儿的带挤奶.
评估对死亡,腹腔内出血和支气管肺形的复合结果的影响.

主要方法:

在8个意大利NICU进行随机临床试验 (PCI试验).
招募了209名早产新生儿 (怀孕23至29周).
干预措施:完整的胎盘循环 (180s) 和带挤奶 (早期紧<20s).

主要成果:

复合结局发生在33% (胎盘循环) 和38% (带挤奶) 的患者中.
在初级复合结果中没有显著差异 (OR,0.83;95% CI,0.47-1.47;P=.53).
二次结果也显示没有显著差异.

结论:

3分钟的完整的胎盘循环复苏与带奶相比,并没有减少早产婴儿的不良结果.
可能需要进一步的研究来优化极度早产婴儿的复苏策略.
试验注册:NCT02671305.5. 试验注册:NCT02671305. 试验注册:NCT02671305. 试验注册:NCT02671305. 试验注册:NCT02671305. 试验注册:NCT02671305. 试验注册:NCT02671305.

更多相关视频

The Perinatal Asphyxiated Lamb Model: A Model for Newborn Resuscitation

The Perinatal Asphyxiated Lamb Model: A Model for Newborn Resuscitation

Published on: August 15, 2018

Ex Vivo Perfusion of the Rodent Placenta

Ex Vivo Perfusion of the Rodent Placenta

Published on: May 30, 2019

相关概念视频

Fetal Circulation

Fetal Circulation

Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...