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化疗后执行功能和日常活动中的表现变化的特征:一个前后混合方法研究协议
Khawla Loubani1,2, Debbie Rand3, Abed Agbarya4,5
1Faculty of Health Sciences, Occupational Therapy Department, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
PloS one
|December 13, 2024
概括
化疗可以损害执行功能 (EF),影响日常活动. 这项研究跟踪了EF变化及其对癌症患者治疗前后日常表现的影响.
科学领域:
- 在瘤学瘤学.
- 神经科学是一个神经科学.
- 康复 康复 康复 康复
背景情况:
- 化疗经常导致认知障碍,特别是执行功能 (EF) 缺陷.
- 这些EF缺陷可能会对癌症患者执行日常活动的能力产生负面影响.
- 了解这些变化对于支持性护理至关重要.
研究的目的:
- 在接受化疗的癌症患者中研究执行功能 (EF) 的变化.
- 评估化疗诱导的EF变化对日常活动表现的影响.
- 通过定性数据探索患者的体验.
主要方法:
- 融合平行混合方法前后实验设计.
- 研究了成年癌症患者 (I-III阶段,非中枢神经系统恶性病) 在化疗前和后 (12周).
- 评估日常活动表现 (加拿大职业绩效指标),EF,认知,疲劳和情感福祉;通过开放式问题提供定性数据.
主要成果:
- 在化疗前,没有报告日常活动存在重大困难.
- 化疗后,执行功能障碍变得明显.
- 该研究确定了EF赤字与日常活动表现下降之间的明显联系.
结论:
- 整合定量和定性数据提供了对认知变化的整体观点.
- 这些发现强调了需要采取干预措施来缓解认知衰退的必要性.
- 有效的干预措施可以帮助尽量减少化疗后日常活动的恶化.
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