Ptch/SPOUT1甲基转移酶在28SRNA上沉积了一种m3U修饰,用于和人类正常的核糖体功能

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Updated: Jun 5, 2025

ACT1-CUP1 Assays Determine the Substrate-Specific Sensitivities of Spliceosomal Mutants in Budding Yeast
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ACT1-CUP1 Assays Determine the Substrate-Specific Sensitivities of Spliceosomal Mutants in Budding Yeast

Published on: June 30, 2022

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Jie Chen1,2, Yaofu Bai1, Yuantai Huang3

  • 1MOE Key Lab of Rare Pediatric Diseases, Hengyang College of Medicine, University of South China, Hengyang, China.

Science advances
|December 13, 2024
PubMed
概括

研究人员在Drosophila中确定了一种特定的RNA修饰,N3-甲基尤里丁 (m3U),并发现Ptch酶对其产生至关重要. 这种修改对核糖体功能至关重要,可能是癌症治疗的目标.

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