通过使用HDL-胆固醇作为预测因素,评估脂乙醇水平之间的酒精消费
Alexander Årving1, Thor Hilberg2, Elisabeth Wiik Vigerust2
1Department of Forensic Sciences, Oslo University Hospital, P.O. Box 4950 Nydalen, Oslo 0424, Norway.
Alcohol and alcoholism (Oxford, Oxfordshire)
|December 13, 2024
概括
这项研究表明,氨酸乙醇 (PEth) 水平与高密度脂蛋白胆固醇 (HDL-C) 相相关,使得可以估计人口的平均每日酒精消费量. 较高的PEth水平表明乙醇摄入量增加.
科学领域:
- 临床化学 临床化学
- 毒理学 毒理学 毒理学
- 生物标志物 生物标志物
背景情况:
- 众所周知,高密度脂蛋白胆固醇 (HDL-C) 水平与饮酒相关.
- 脂乙醇 (PEth) 是饮酒量的一个直接生物标志物.
研究的目的:
- 探索酸乙醇 (PEth) 含量与乙醇消耗之间的关联.
- 用HDL-C作为替代标志物来估计人口水平的酒精摄入量.
主要方法:
- 在挪威,从29,899名患者的50,751个样本中同时测量PEth和HDL-C.
- 线性混合模型分析以评估不同PEth间隔内的HDL-C水平.
- 根据每克乙醇的确定的HDL-C增加,估计平均每天的乙醇摄入量.
主要成果:
- 在PEth和HDL-C水平之间发现了显著的相关性 (斯皮尔曼的rho=0.385对于女性,0.420对于男性,P<.001).
- 增加PEth水平与更高的估计平均HDL-C相关,因此,酒精消费量更高.
- 男性PEth .031-0.100 μmol/L估计平均每日摄入约20g的乙醇;那些PEth .301-0.500 μmol/L估计约51g的人.
结论:
- 可以使用PEth水平来估计小组一级的平均每日乙醇消耗量.
- 该方法补充了现有的酒精消费评估工具.
- 研究结果支持将PEth与HDL-C结合用于酒精摄入量监测.
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