纽尔图林基因IVSI-663多态,但不是RET变异与乳腺癌风险增加有关
Tuba Taşkan1, Farshad Noori2, Osman Kurukahvecioğlu3
1Afyonkarahisar Health Sciences University, Faculty of Pharmacy, Department of Biochemistry, Afyonkarahisar, Türkiye.
Laboratory medicine
|December 13, 2024
概括
在NRTN基因IVSI-663多态的G等位基因增加乳腺癌的风险. 患者血清NRTN和FAK水平升高表明乳腺癌的诊断和治疗潜力.
科学领域:
- 遗传学 是一个遗传学.
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 在癌症发病过程中研究转染过程中重新排列 (RET) 和神经素 (NRTN) 的基因多态性.
- 专注于癌症的入侵和转移.
- 检查特定的RET和NRTN多形态在乳腺癌发展中的作用.
研究的目的:
- 评估与RET G691S,L769L,S904S和NRTN IVSI-663多态度相关的乳腺癌风险.
- 在乳腺癌患者中评估NRTN,脑衍生神经营养因子 (BDNF),矩阵金属蛋白酶 (MMP) -2,MMP-9和焦粘附激酶 (FAK) 的血清水平.
主要方法:
- 研究包括110名乳腺癌患者和110名对照.
- 在全血样本上使用聚合酶链反应 (PCR) 分析的多态.
- 在患者和对照组中测量血清生物标志物水平.
主要成果:
- NRTN IVSI-663 G等位基因与乳腺癌风险增加1.54倍相关 (P < .05).
- NRTN IVSI-663 AA 基因型显示风险降低了0.43倍 (P < .05).
- 在乳腺癌患者中观察到血清NRTN和FAK水平升高,MMP-2和MMP-9水平降低 (P < .05).
结论:
- NRTN基因IVSI-663多态,特别是G等位基因,与乳腺癌风险增加有关.
- 患者血清NRTN和FAK水平升高可能有助于诊断和预后.
- 这些发现可能会为乳腺癌的新治疗策略提供信息.
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