超薄型基于高的酸的可注射水凝具有编程的杀菌和抗炎作用,以加速耐药细菌感染的伤口愈合
Mingming Zhang1, Huaping Jia1, Liang Zhuang2
1The Ninth Medical Center of Chinese PLA General Hospital, 9 Anxiang Beili, Chaoyang District, Beijing 100101, China.
Colloids and surfaces. B, Biointerfaces
|December 13, 2024
概括
这项研究引入了一种智能水凝,用于治疗耐药细菌伤口感染. 它有效地使用声动疗 (SDT) 杀死细菌,然后通过清除活性氧物种 (ROS) 来减少炎症.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 伤口愈合 治愈 伤口愈合
背景情况:
- 伤口中耐药性细菌感染阻碍了伤口的愈合,增加了死亡风险.
- 声动疗 (SDT) 有效地消除了耐药细菌,但产生了过度的活性氧物种 (ROS),导致炎症和阻碍组织修复.
- 现有的治疗方法难以平衡强大的抗菌作用和受控的抗炎反应.
研究的目的:
- 开发一种智能,可注射的水凝,用于编程感染伤口中的抗菌和抗炎作用.
- 为了利用超薄高的酸 (UHE-HTs) 和尼古丁胺胺单核酸 (NMN) 进行受控的ROS管理和炎症抑制.
- 创建一种双重作用的治疗系统,消除细菌并促进伤口再生.
主要方法:
- 开发一种可注射,热敏的水凝,其中包括UHE-HTs和NMN (UHE-HTs/PFN).
- 在体外和体内评估水凝的声敏单片氧 (O2) 产生用于杀死细菌.
- 评估水凝通过氧化还原酶模仿催化和NMN释放来清除ROS的能力,抑制NF-κB和热的途径.
主要成果:
- 在超声波下通过O2生产,UHE-HTs/PFN水凝证明了多抗药性 (MDR) 细菌的有效杀菌.
- 在照射后,水凝有效降低了ROS水平,抑制了NF-κB和热致死 (NLRP3 / ASC / Casp-1) 途径,并减轻了炎症.
- 水凝促进了从促炎转向再生伤口微环境的转变,由减少ROS和协同释放的Mg2+证明.
结论:
- 开发的UHE-HTs/PFN水凝为治疗受感染的伤口提供了一个平衡的方法,有效地消灭细菌,同时控制炎症.
- 这种智能水凝系统作为一个"杆"来管理ROS生成和消灭,促进伤口愈合.
- 这项研究提出了一项有希望的战略,以应对与耐药细菌感染相关的挑战,并促进组织再生.
相关概念视频
Inflammatory Response II: Inflammatory Exudate and Tissue Repair
The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the exudate's...
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the exudate's...
Hand hygiene
Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
Hand washing...
Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents
In the intricate landscape of the gastric lumen, excessive acid secretion disrupts the natural defense mechanisms, weakening the mucus-bicarbonate barrier. This vulnerability allows pepsin to infiltrate epithelial cells, digesting mucosal proteins and triggering erosion, leading to ulcer formation.
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
Waterproofing and Anti-Bacterial Admixtures in Concrete
Concrete's susceptibility to water absorption is due to the capillary action within the pores of its hydrated cement paste. This action draws water in, creating the need for waterproofing admixtures to prevent such penetration. The efficacy of these admixtures is contingent upon the water pressure, with variations arising from different conditions such as rain, capillary rise, or hydrostatic pressure in structures intended to hold water.
Waterproofing admixtures render concrete hydrophobic,...
Waterproofing admixtures render concrete hydrophobic,...
Chemical Agents for Microbial Control
Chemicals play important roles in controlling microbial growth by targeting microbial structures and functions as sanitizers, antiseptics, disinfectants, and sterilants.Alcohols are commonly used sanitizers, effectively disrupting lipid membranes, which compromises cell integrity. They are also used as antiseptics and disinfectants due to their rapid action and versatility.Phenols and their derivatives phenolics , known for denaturing proteins and disrupting cell membranes, are particularly...
Determinants of Bacterial Pathogenicity and Virulence
Pathogenic bacteria employ a variety of strategies to establish infections, including the secretion of extracellular enzymes that act as potent virulence factors. These enzymes facilitate bacterial colonization of host tissues and help evade immune surveillance. By targeting structural components of host tissues and interfering with immune mechanisms, these enzymes play a pivotal role in disease progression.Extracellular Enzymes Facilitating Tissue Invasion: Several bacterial pathogens secrete...


