在创伤性大脑分析中,两个最大主张应变率计算方案之间的差异与体内和体内数据集
Xianghao Zhan1, Zhou Zhou2, Yuzhe Liu3
1Department of Bioengineering, Stanford University, CA, 94305, USA.
Journal of biomechanics
|December 13, 2024
概括
计算最大主要应变率 (MPSR) 的两种方法产生了类似的创伤性脑损伤 (TBI) 预测准确度. 尽管计算方法有差异,但MPSR和MPS × SR方法都有效地检测TBI,错误率最小.
科学领域:
- 生物力学 生物力学
- 神经科学是一个神经科学.
- 伤害力学 伤害力学
背景情况:
- 创伤性脑损伤 (TBI) 的预测依赖于大脑变形指标,如最大主要应变 (MPS).
- 结合最大主张率 (MPSR) 和MPS × SR,可以提高TBI预测的准确性.
- 在MPSR计算中存在模糊性:MPS的时间导数 (MPSR1) 与延展率张数 (MPSR2) 的第一个自值.
研究的目的:
- 为了量化MPSR1和MPSR2计算方法之间的差异.
- 为了比较使用MPSR1/MPS × SR1与MPSR2/MPS × SR2的TBI模型的预测性能.
- 调查滥用MPSR和MPS × SR值对TBI检测的影响.
主要方法:
- 在八个in-vivo和一个in-silico头部撞击数据集中对MPSR1和MPSR2进行比较.
- 计算MPSR1,MPSR2,MPS × SR1和MPS × SR2的平均值和第95百分位数值.
- 训练物流回归模型以使用MPSR和MPS × SR指标预测TBI.
主要成果:
- 在所有影响方面,平均MPSR1比MPSR2小12.73%,MPS × SR1比MPS × SR2小11.95%.
- 第95个百分点MPSR1略大于第95个百分点MPSR2,而第95个百分点MPS × SR1平均比第95个百分点MPS × SR2大4.85%.
- 创伤预测模型显示,两种MPSR计算方法的准确性没有显著差异,滥用值导致~1%的错误率.
结论:
- 两种MPSR计算方法 (MPSR1和MPSR2) 呈现出可量化的差异,但不会显著影响TBI预测的准确性.
- MPS × SR1和MPS × SR2也表现出差异,但保持了可比的预测性能.
- 目前的证据表明,MPSR计算方法中的任何一种都适用于TBI检测,但门一致性至关重要,以避免错误分类.
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