产前臭氧暴露和儿童肺功能:通过氧化平衡得分来探索效应的改变
Logan C Dearborn1, Marnie F Hazlehurst1, Melissa M Melough2
1Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA.
International journal of hygiene and environmental health
|December 13, 2024
概括
产前臭氧暴露没有显示出与儿童肺功能有很强的联系. 然而,一些子组,如低氧化平衡得分的黑人女性,可能更容易受到伤害.
科学领域:
- 环境健康 环境健康
- 儿科肺病学 儿科肺病学
- 生殖流行病学 生殖流行病学
背景情况:
- 产前暴露于臭氧 (O3) 可能会对儿童肺部发育产生负面影响.
- 氧化应激途径与臭氧对终身健康的影响有关.
- 通过氧化平衡得分 (OBS) 评估的饮食可能会改变这些影响.
研究的目的:
- 调查产前臭氧暴露与8-9岁儿童肺功能之间的关联.
- 探索孕产妇的饮食 (OBS) 和种族是否会改变产前臭氧对肺功能的影响.
主要方法:
- 使用了来自CANDLE队列 (ECHO-PATHWAYS联盟的一部分) 的螺旋计数据.
- 估计的产前臭氧 (O3) 暴露使用一个时空模型跨关键胎儿肺发育窗口.
- 使用线性回归模型与相互作用术语来评估由OBS和母体种族对效果的修改.
主要成果:
- 在初级分析中,产前臭氧暴露与儿童肺功能之间没有发现强有力的关联.
- 在怀孕晚期的臭氧暴露 (囊性窗口) 和FEV1/FVC和FEF25-75.5之间注意到了暗示性的不良关联.
- 探索性分析表明,在三方相互作用中,OBS和母体种族的潜在效果改变,尽管数据稀少.
结论:
- 这项研究没有发现强有力的证据将产前臭氧暴露与儿童肺功能受损联系起来.
- 探索性发现表明潜在的子组漏洞需要进一步调查.
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