消费益生菌可以保护人体免受来自大米消费的暴露,同时促进肠道健康:基于小鼠模型的评估
Jin-Feng Xi1, Lei Zhou1, Yao-Sheng Zhang1
1State Key Laboratory of Pollution Control and Resource Reuse, Jiangsu Key Laboratory of Vehicle Emissions Control, School of Environment, Nanjing University, Nanjing 210023, China.
The Science of the total environment
|December 13, 2024
概括
益生菌可以减少水中的吸收,特别是当和铁足够时. 这一策略还通过促进有益的细菌和减少炎症来改善肠道健康.
科学领域:
- 环境健康 环境健康
- 微生物学 微生物学
- 营养科学 营养科学
背景情况:
- 米中的 (Cd) 构成全球健康风险.
- 需要采取战略来降低Cd的生物可用性并改善健康.
- 益生菌通过结合Cd和改善肠道健康提供了一个潜在的解决方案.
研究的目的:
- 为了评估Akkermansia muciniphila,Bifidobacterium pseudolongum和Psychrobacter sp.的影响. 关于Cd在米中的生物可用性.
- 评估这些益生菌对小鼠肠道健康的影响.
- 确定 (Ca) 和铁 (Fe) 在益生菌疗效中的作用.
主要方法:
- 在活体中进行了小鼠生物测试.
- 进行了体外Cd固定试验.
- 给小鼠食Cd污染的米饭,有或没有矿物质补充剂.
主要成果:
- 在矿物质缺乏的情况下,益生菌由于对Ca和Fe的竞争,导致Cd积累的减少有限.
- 在矿物质充足的情况下,益生菌摄入显著降低了脏Cd度 (60.0%-72.0%).
- 益生菌促进了有益的肠道细菌,加强了肠道紧密的结节,并减少了肠道炎症.
结论:
- 适当的饮食摄入Ca和Fe对于益生菌有效降低Cd生物可用性至关重要.
- 将益生菌与足够的Ca和Fe结合在一起,是减轻饮食中的Cd暴露的有希望的策略.
- 益生菌的消费增强了肠道健康,提供了除了减少Cd之外的额外健康益处.
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