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用添加剂制造的骨科植入物PEEK/HA多孔结构的机械行为:材料,结构和制造工艺

Qing Zhang¹, Changning Sun², Jibao Zheng²

¹State Key Laboratory for Manufacturing System Engineering, School of Mechanical Engineering, Xi'an Jiaotong University, 710054, Xi'an, ShaanXi, China; National Medical Products Administration (NMPA) Key Laboratory for Research and Evaluation of Additive Manufacturing Medical Devices, Xi'an Jiaotong University, 710054, Xi'an, ShaanXi, China; Centre for Medical Device Evaluation, National Medical Products Administration (NMPA), 100081, Beijing, China.

Journal of the mechanical behavior of biomedical materials

|December 13, 2024

概括

这项研究优化了聚乙-乙- (PEEK) /酸 (HA) 骨架的骨质整合. 这些发现指导了多孔PEEK植入物的设计,具有量身定制的透性和机械性能,以增强骨生长.

科学领域:

生物材料科学生物材料科学
整形外科工程整形外科工程
增材制造增材制造增材制造

背景情况:

聚乙乙基 (PEEK) 的生物惰性限制了在骨植入物中的骨质整合.
多孔PEEK支架的增材制造显示出改善骨生长和稳定性的前景.
基于PEEK的复合材料支架的最佳设计策略仍然不清楚.

研究的目的:

系统地调查材料组成,结构设计和制造对PEEK/酸 (HA) 脚手架透性和机械性能的影响.
制定PEEK/HA支架的设计准则,以促进骨质整合.
评估热处理对脚手架性能的影响.

主要方法:

使用增材制造制造制造PEEK/HA支架的制造,具有不同孔径和结构 (甲状腺,直角).
通过不同的脚手架设计和深度测量轴向和周边透率.
热处理后的机械性能 (弹性模量,屈服强度) 和结晶性的表征.

主要成果:

透度在0.3-24.8 × 10^-9 m^{2之间;状结构的透度低于直角结构.}
机械性能 (弹性模量,屈服强度) 与相对密度为35-50%的脚手架的人类无骨骨相比.
热处理增强了强度和刚度,达到37.2%的晶度,但过度的晶度导致了脆性.

结论:

材料组成,结构设计和制造工艺都会对PEEK/HA脚手架的透性和机械性能产生重大影响.
脚手架的设计和加工参数可以优化,以实现适合骨生长的特性.
这项研究为开发先进的基于PEEK的多孔骨植入物提供了关键的见解.

关键词:

增材制造增材制造是一种增材制造.机械性质机械性质骨质整合骨质整合标签: 皮克 / 哈皮克 / 哈透性透性的孔隙结构孔隙结构

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