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通过核因子-κB激活,母亲暴露于阿斯巴甜会改变后代的肺Th1/Th2细胞因子平衡

Hsiao-Chi Chuang¹, Yu-Chen S H Yang², Hsiu-Chu Chou³

¹School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.

International immunopharmacology

|December 13, 2024

概括

孕妇在怀孕和哺乳期间摄入的阿斯巴甜可能会通过改变免疫反应影响后代的肺部健康. 这项研究发现,它扭曲了Th1/Th2细胞因子平衡,并在后代肺部激活了核因子-kB.

科学领域:

免疫学免疫学免疫学
毒理学毒理学毒理学
微生物组研究微生物组研究

背景情况:

流行病学研究将母亲的非营养甜味剂摄入与儿童喘联系起来.
阿斯巴甜是一种常见的非营养甜味剂,具有潜在的健康影响.

研究的目的:

为了研究母亲暴露于阿斯巴甜对后代肺免疫平衡的影响.
探索肠道微生物群和核因子-κB (NF-κB) 激活在调解这些效应中的作用.

主要方法:

怀孕的小鼠在怀孕和哺乳期间接受了水或阿斯巴甜补充水.
对后代的肺组织和肠道微生物群进行了免疫标志物和微生物组成的分析.
测量了免疫球蛋白E (IgE) 水平和细胞因子 (Th1/Th2) 概况.

主要成果:

孕产妇接触阿斯巴甜会增加后代的体重,并增加Th2细胞因子 (IL-4,IL-5,IL-13),IL-17和IgE.
观察到Th1细胞因子干扰素- (IFN-γ) 的降低,表明Th1/Th2平衡发生了变化.
在后代的肺部观察到核因子-κB (NF-κB) 激活的增加,而肠道微生物群的组成保持不变.

结论:

孕产妇接触阿斯巴甜会影响后代的肺Th1/Th2细胞因子平衡.
核因子-κB (NF-κB) 激活似乎是调解这些免疫变化的关键机制.

关键词:

亚斯巴甜胺是一种喘喘是一种核因子-κBB 的核因子.辅助T细胞是T细胞的辅助细胞.这是一个很好的方法. Th1 Th1 Th1 Th17 这是一个很好的方法.Th2 Th2 的意思是什么?

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