缺氧作为细胞外囊泡介导的瘤细胞与周围微环境之间的细胞间通信的关键参与者
Helena Branco1, Cristina P R Xavier2, Chiara Riganti3
1i3S - Instituto de Investigação e Inovação em Saúde, University of Porto, 4200-135 Porto, Portugal; Cancer Drug Resistance Group, IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto, 4200-135 Porto, Portugal; Department of Biological Sciences, FFUP - Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
细胞外囊泡 (EVs) 在癌症中调解细胞间通信. 本综述探讨了瘤微环境 (TME) 中缺氧或低氧如何影响EV及其在癌症进展和细胞信号传递中的作用.
科学领域:
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
- 生物化学 生物化学
背景情况:
- 细胞外囊泡 (EVs) 是癌症细胞间通信的关键媒介,转移驱动恶性进展的分子.
- 缺氧 (低氧) 是固体瘤的标志,显著影响癌症预后和治疗反应.
- 瘤细胞适应低氧条件,促进亲瘤表型,并可能增加循环的EVs.
研究的目的:
- 审查细胞外囊泡 (EVs) 在低氧瘤微环境 (TME) 内调解细胞间通信中的作用.
- 探索缺氧如何影响癌症中的EV产生和功能.
- 在低氧性TME中,检查瘤细胞与周围的树皮细胞,免疫细胞和内皮细胞之间的EVs介导的交叉声.
主要方法:
- 文献综述侧重于研究细胞外囊泡 (EV) 和癌症中缺氧的研究.
- 对瘤微环境 (TME) 中EV介导细胞间通信现有证据的分析.
- 综合与低氧对EV含量和功能的影响相关的发现.
主要成果:
- 在TME中缺氧与癌症患者中循环EVs水平升高有关.
- 建议EV调解细胞间通信,以应对缺氧条件.
- EVs促进瘤细胞和 hypoxic TME 内的各种细胞群 (免疫,内皮细胞,树皮细胞) 之间的交叉声调.
结论:
- 细胞外囊泡 (EVs) 在低氧瘤微环境 (TME) 内的细胞间通信中发挥着关键作用.
- 缺氧会影响EV介导的信号传输,导致癌症的进展和治疗耐药性.
- 了解EV-低氧相互作用对于开发新的癌症诊断和治疗方法至关重要.
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