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科利登® SR:配方技术和药物输送应用

Safwan Abdel Rahim1, Nizar Al-Zoubi2, Shadi Gharaibeh3

  • 1Department of Pharmaceutical Sciences and Pharmaceutics, Faculty of Pharmacy, Applied Science Private University, Amman 11931, Jordan.

International journal of pharmaceutics
|December 13, 2024
PubMed
概括

科利登 (Kollidon® SR) 是一种聚乙烯酸和聚乙烯酸的辅助剂,可提供多功能修饰释放剂的剂型开发. 它使各种配方技术和定位投放成为可能,确保可靠的药物释放和稳定性.

关键词:
同处理的辅助剂.配方技术 配方技术的使用科利登® SR 是一种修改后的发布版本 修改后的发布版本针对地点的药物输送是有针对性的

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
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Drug Delivery: Enteral Route

The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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