对阿片类药物使用障碍患者进行联合药物和行为激活治疗 (CoMBAT) 的初步随机对照试验
Jaclyn M W Hughto1, Landon D Hughes2, Kimberly M Nelson3
1Department of Behavioral and Social Sciences, Brown University, School of Public Health, Providence, RI, USA; Department of Epidemiology, Brown University, School of Public Health, Providence, RI, USA; COBRE on Opioids and Overdose, Rhode Island Hospital, Providence, RI, USA; Center for Health Promotion and Health Equity, Brown University, Providence, RI, USA; Center for Alcohol and Addiction Studies, Brown University, Providence, RI, USA; The Fenway Institute, Fenway Health, Boston, MA, USA.
Journal of substance use and addiction treatment
|December 13, 2024
概括
联合药物和行为激活治疗 (CoMBAT) 干预对于患有阿片类药物使用障碍和抑郁症的人来说是可行的和可以接受的. 它改善了MOUD护理的参与度,并减少了阿片类药物的使用.
科学领域:
- 成 药物 药物 药物 药物
- 行为心理学 行为心理学
- 精神病学是一个精神病学.
背景情况:
- 阿片类药物使用障碍 (OUD) 是一种具有显著发病率和死亡率的慢性疾病.
- 治疗阿片类药物使用障碍 (MOUD) 的药物是有效的,但治疗的维持通常是不理想的.
- 抑郁症是治疗失效的关键因素,需要进行行为干预.
研究的目的:
- 评估联合药物和行为激活治疗 (CoMBAT) 干预措施的可行性,可接受性和初步疗效.
- 评估CoMBAT是否可以降低抑郁症,增加目标导向活动,并改善MOUD护理参与度.
- 确定干预措施对减少成年人患有抑郁症状的阿片类药物使用的影响.
主要方法:
- 进行了一项试点随机对照试验,其中32名参与者被处方MOUD.
- 参与者接受了CoMBAT加健康导航/物质使用咨询 (HN_SUC) 或单独接受HN_SUC.
- 结果包括可行性,可接受性,MOUD护理参与,抑郁症状,行为激活和阿片类药物使用,评估时间为3个月和6个月.
主要成果:
- 科姆巴特干预表明了高可行性 (88%的会议完成) 和可接受性 (86%的满意度).
- 在CoMBAT组的参与者显示,在6个月后,MOUD错过的剂量/访问减少,抑郁症状减少.
- CoMBAT组也表现出增加的行为激活和较低的阿片类药物阳性毒理学查的百分比.
结论:
- 对于OUD和抑郁症状的个人来说,CoMBAT干预是可行的和可以接受的.
- 初步发现表明,它可以改善MOUD护理参与度,减少抑郁症和减少阿片类药物使用.
- 建议在全功率的疗效试验中进行进一步的研究,以证实这些结果.
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