在子宫内膜异位症中,情绪变化和抑郁症限制了口服避孕药治疗
E Cansu Cevik1, Hugh S Taylor1
1Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut.
Fertility and sterility
|December 13, 2024
概括
患有子宫内膜异位症的妇女在口服避孕药 (OCs) 上经历了更多的情绪变动和抑郁,导致更高的中止率. 对于那些有风险或经历情绪变化的人来说,建议早期考虑替代疗法.
科学领域:
- 生殖医学 生殖医学
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 子宫内膜异位症显著影响妇女的生活质量.
- 口服避孕药 (OCs) 是对子宫内膜异位症的常见治疗方法.
- 情绪障碍是OCs的一个潜在副作用.
研究的目的:
- 调查口服避孕药 (OC) 诱导的情绪不稳定和抑郁对子宫内膜异位症妇女治疗坚持的影响.
- 为了评估先前存在的抑郁症和因情绪变化而停止OC治疗之间的关联.
主要方法:
- 在2012年至2024年期间治疗了2,682名患有子宫内膜异位症的女性 (18-45岁) 的医疗记录的回顾性审查.
- 识别OC停药的原因,特别是情绪不稳定/抑郁.
- 基于抑郁症诊断和OC类型 (联合与仅用孕激素) 的停药率的比较.
主要成果:
- 44.2%的子宫内膜异位症妇女停止了OCs; 33.9%的人表示情绪不稳定/抑郁.
- 在OCs上患有子宫内膜异位症的女性表现出情绪不稳定性/抑郁症的增加,增加了停止治疗的可能性.
- 由于情绪变化而停止使用OCs的人中,抑郁症的诊断更为普遍 (52.7%).
结论:
- 患有子宫内膜异位症的女性患抑郁症的发病率更高,并且由于情绪障碍,更有可能停止OCs.
- 情绪不稳定是这一群体中OC停止的重要因素.
- 对于有风险的子宫内膜异位症患者或经历OCs的情绪变化患者,应早期考虑替代性治疗策略.
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