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在美国非糖尿病人群中,多次接触农药和血糖调节受损

Xingdi Zhu¹, Congxin Chen², Qi Liu²

¹Department of Obstetrics and Gynecology, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, 210004, China; First School of Clinical Medicine, Nanjing Medical University, Nanjing, 211100, China.

Environmental pollution (Barking, Essex : 1987)

|December 13, 2024

概括

农药暴露,特别是有机农药 (OPs),与美国成年人的葡萄糖调节受损和糖尿病前期有关. 这种联系在老年人中更强烈,这表明早期糖尿病预防策略的潜力.

科学领域:

环境健康环境健康
代谢障碍代谢障碍代谢障碍
毒理学毒理学毒理学

背景情况:

糖尿病前期是一种重要的代谢障碍,经常被忽视,患2型糖尿病的进展率很高.
农药的糖尿病效应是众所周知的,但它们与糖尿病前期的联系仍未得到充分研究.
调查农药暴露对于了解和预防不断升级的糖尿病流行病至关重要.

研究的目的:

评估在美国非糖尿病人群中暴露于常见的尿路农药和受损葡萄糖调节 (IGR) 之间的关联.
专门研究有机农药 (OPs),铁,除草剂和糖尿病前期,包括胰岛素耐药性之间的关系.

主要方法:

对三个类型的尿路农药进行分析:有机农药 (OPs), pyrethroids 和除草剂.
使用了通用线性回归,受限立方线和贝叶斯内核机器回归 (BKMR) 模型.
评估糖尿病前期 (禁食葡萄糖[IFG]和/或葡萄糖耐受性[IGT]) 和胰岛素抵抗.

主要成果:

3,5,6-三烯醇 (TCPY) 与糖尿病前期和葡萄糖耐受性损害 (IGT) 有积极的线性关联.
马拉二酸 (MDCA) 和帕拉尼托芬醇 (PNP),这两种OP代谢物,与胰岛素耐药性增加的几率有关.
在混合物暴露分析中,TCPY,MDCA和PNP是主要的贡献者;随着年龄的增长,关联变得更加明显.

结论:

研究结果表明,有机农药暴露与葡萄糖调节受损之间存在显著关系,特别是在老年人中.
这项研究强调了农药暴露在糖尿病发展早期的潜在作用.
通过解决环境暴露,结果为针对2型糖尿病的有针对性的预防策略提供了见解.

关键词:

禁食葡萄糖受损禁食葡萄糖受损葡萄糖耐受性受损的情况.胰岛素耐药性胰岛素耐药性是一种杀虫剂是一种杀虫剂.糖尿病前期的情况.

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