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对于天花疫苗的斑块减少中和试验:用于免疫性评估的实验室优化和验证方法.

Hyun-Jung Kong1, You-Jin Kim1, Dokeun Kim1

  • 1Division of Infectious Disease Vaccine Research, Center for Vaccine Research, National Institute of Infectious Diseases, National Institute of Health, CheongJu, Chungbuk, Republic of Korea.

Journal of immunological methods
|December 13, 2024
PubMed
概括

一个经过验证的斑块减少中和试验 (PRNT) 可靠地测量疫苗病毒 (VACV) 中和抗体. 这种测定对于评估新的天花疫苗至关重要,确保公共卫生对病毒威胁的准备.

关键词:
中和抗体的抗体在 PRNT 中使用.标准化 标准化 标准化疫苗病毒是疫苗病毒.验证 验证 验证 验证

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Smallpox01:24

Smallpox

Smallpox is a severe contagious disease caused by the Variola major virus, a double-stranded DNA member of the Poxviridae family.Variola major transmission occurs primarily via inhalation of virus-laden droplets or direct contact with infectious scabs. The incubation period averages approximately seven days, although it may range from 7 to 17 days depending on the inoculum and host factors.Clinically, the prodromal phase is marked by an abrupt onset of high fever, malaise, headache, and myalgia.