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相关概念视频

Oogenesis02:07

Oogenesis

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In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
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Updated: Jun 5, 2025

Cell-Specific Paired Interrogation of the Mouse Ovarian Epigenome and Transcriptome
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通过激活cGAS-STING通路并降低小鼠卵细胞质量,托利德暴露会触发卵巢炎症.

Si-Yao Cheng1, Yi-Fan Yang1, Ya-Long Wang2

  • 1Medical College, Guangxi University, Nanning, Guangxi, 530004, China.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
|December 13, 2024
PubMed
概括

ptolide (TPL) 通过影响线粒体功能和激活炎症通路而导致卵巢损伤. 这导致生育能力和卵细胞质量下降,阻碍卵泡发育.

关键词:
在表观遗传学上,表观遗传学是表观遗传学.卵巢 卵巢 卵巢三托利德是一种三托利德.在cGAS-STING路径中.释放mtDNA的时间

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科学领域:

  • 毒理学 毒理学 毒理学
  • 生殖生物学 生殖生物学
  • 分子生物学分子生物学

背景情况:

  • 来自Tripterygium wilfordii的Triptolide (TPL) 具有抗瘤和抗免疫用途.
  • TPL导致多器官毒性,包括女性生殖系统损伤.
  • 由于TPL引起的卵巢损伤的机制尚不清楚.

研究的目的:

  • 研究TPL诱导的卵巢毒性的机制.
  • 评估TPL对卵巢功能和卵细胞质量的影响.
  • 确定涉及TPL生殖副作用的分子途径.

主要方法:

  • 对于TPL暴露的小鼠毒理模型.
  • 评估卵巢系数和生育能力.
  • 对线粒体功能,mtDNA释放和cGAS-STING通路激活的分析.
  • 评估卵细胞中介性成熟,螺旋和MTOC形态.
  • 减少表示双硫酸盐序列 (RRBS) 进行确认.

主要成果:

  • 在小鼠中,TPL暴露降低了卵巢系数和生育能力.
  • TPL破坏了线粒体功能,导致mtDNA释放和cGAS-STING通路激活.
  • 观察到卵巢炎症和卵泡发育障碍.
  • TPL 损害了卵细胞中介成熟,影响了螺旋和MTOCs.

结论:

  • TPL通过线粒体功能障碍和炎症途径诱导卵巢损伤.
  • 毛囊发育受损和卵细胞质量下降是TPL暴露的关键后果.
  • 了解这些机制对于管理TPL的生殖毒性至关重要.