维生素D和/或可以预防骨折和跌倒:系统审查和元分析的协议
Olivier Massé1, Claudia Mei Mercurio2, Sébastien Dupuis2
1Department of pharmacy, Hôpital du Sacré-Coeur-de-Montréal, Montréal, Québec, Canada olivier.masse.cnmtl@ssss.gouv.qc.ca.
BMJ open
|December 13, 2024
概括
本系统性审查评估了维生素D和补充剂用于预防骨折和跌倒. 目前的证据表明有效性有限,质疑普遍推成人普遍补充剂的广泛建议.
科学领域:
- 老年学是一门学科.
- 营养科学 营养科学
- 基于证据的医学基于证据的医学.
背景情况:
- 之前的系统性审查表明,或维生素D单疗对预防骨折和跌倒的有效性有限.
- 关于维生素D和的联合疗效存在相互矛盾的发现.
- 尽管证据不尽相同,临床医生和指导方针仍然广泛推普遍补充.
研究的目的:
- 系统地审查关于维生素D和/或在预防成年人骨折和跌倒方面的疗效的随机对照试验.
- 综合当前的证据,为临床实践和有关补充剂的政策提供信息.
主要方法:
- 从多个数据库 (Medline,Embase,CENTRAL,ICTRP,ClinicalTrials.gov) 和手动搜索中对随机对照试验的系统审查.
- 包括单独使用,单独使用维生素D或联合治疗与安慰剂的试验.
- 主要结局:骨折;次要结局:部,脊椎,非脊椎骨折和跌倒. 使用Cochrane工具评估偏差风险;使用元分析和GRADE证据确定性.
主要成果:
- 计划对随机对照试验进行数据综合和元分析.
- 亚组和敏感性分析将探讨发现的异质性和稳定性.
- 证据的确定性将使用推评估,开发和评估 (GRADE) 框架进行评估.
结论:
- 这一系统性审查将提供关于维生素D和/或预防骨折和跌倒的最新证据综合.
- 调查结果将为临床医生,指南制定者和监管机构提供关于普遍补充剂有效性的信息.
- 这项研究旨在澄清这些补充剂在维持骨健康和预防成年人跌倒方面的作用.
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