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Updated: Jul 28, 2026

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自强化mRNA疫苗可以保护老年BALB/c小鼠免受致命的呼吸道同胞病毒感染

Lulu Zuo1, Qixing Liu2, Ke Zhang3

  • 1Viral Hemorrhagic Fevers Research Unit, Institut Pasteur of Shanghai (now Shanghai Institute of Immunity and Infection), Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China; Institute of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 201203, China.

Molecular therapy : the journal of the American Society of Gene Therapy
|December 14, 2024
PubMed
概括

自强化mRNA (sa-mRNA) 疫苗对呼吸道同胞病毒 (RSV) 显示出有前途. 在老年小鼠中,低剂量sa-mRNA疫苗诱导了强大的免疫力,并在RSV挑战后有80%以上的存活率.

关键词:
这就是为什么RSV RSV.保护的相关性保护的相关性致命的动物模型呼吸道同胞性病毒这是sa-mRNA疫苗.自强化的mRNA.疫苗 疫苗 疫苗 疫苗

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Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...