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系统性fingolimod治疗对前段参数和膜功能的影响

Atike Burcin Tefon Aribas¹, Semra Mungan², Feyza Dicle Işik¹

¹Department of Ophthalmology, Ankara Bilkent City Hospital, Ankara, Turkey.

Cutaneous and ocular toxicology

|December 14, 2024

概括

多发性硬化症 (MS) 患者的系统性fingolimod治疗可能会改善撕裂膜功能,由增加的Schirmer I测试和撕裂破裂时间 (TBUT) 值表明. 其他前眼段参数在六个月内保持不变.

科学领域:

眼科医生眼科眼科
神经学神经学
药理学药理学是指药理学的学科.

背景情况:

多发性硬化症 (MS) 是一种慢性自身免疫性疾病,影响中枢神经系统.
芬戈利莫德是一种用于治疗复发性多发性硬化症的斯芬戈-1-酸盐受体调节剂.
眼部副作用是MS治疗的一个问题,需要对眼部参数进行评估.

研究的目的:

评估系统性fingolimod对前段眼睛参数的影响.
在MS患者的fingolimod治疗期间评估膜功能测试的变化.

主要方法:

对24名复发性复发性多发性硬化症患者的前性研究,开始系统性fingolimod.
在治疗前1个月和6个月之前,使用Sirius拓学分析前部细分.
通过Schirmer-I测试和撕裂分解时间 (TBUT) 评估的膜功能.
使用光谱域光学连贯性断层扫描 (SD-OCT) 测量视网膜厚度.

主要成果:

在视网膜厚度或大多数前段参数 (角膜厚度,角膜测量,前腔深度,角膜角膜角等) 中没有发现显著变化. ) 的情况.
与基线相比,6个月后的希尔默-I测试值显示出统计学上显著的增加 (p=0.044).
撕裂破裂时间 (TBUT) 在6个月与基线和1个月 (p<0.001) 显著改善,但在基线和1个月 (p=0.419) 之间没有明显改善.

结论:

系统性fingolimod治疗似乎可以增强MS患者的催膜功能.
在Schirmer I和TBUT中观察到的改善表明对眼表面健康的潜在益处.
在6个月的研究期间,芬戈利莫德治疗没有对其他测量的前段参数产生不利影响.

关键词:

在Fingolimod中使用.施里默测试施里默测试施里默测试角膜的地形图是角膜的地形图.多发性硬化症多发性硬化症撕裂的分手时间

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