微生物群和肥胖症的演变
Mario J A Saad1, Andrey Santos1
1Department of Internal Medicine, School of Medical Sciences, University of Campinas, CEP 13083-887 Campinas, SP, Brazil.
Endocrine reviews
|December 14, 2024
概括
肥胖的进化起源可能与为病原体防御选择的基因有关,这一概念称为元炎症. 肠道微生物组遗传学进一步使肥胖流行病复杂化,需要多方面的方法来理解其复杂的根源.
科学领域:
- 进化生物学是进化的生物学.
- 人类遗传学 人类遗传学
- 免疫学 免疫学 免疫学
背景情况:
- 肥胖是一个重要的全球健康问题,其起源复杂.
- 现有的假设包括节/漂流的基因型和改变的发热.
- 遗传和环境因素的作用已被证实.
研究的目的:
- 为肥胖的进化起源提出元炎症假说.
- 探索免疫防御基因与现代肥胖之间的联系.
- 将肠道微生物群的影响纳入肥胖的遗传框架.
主要方法:
- 关于肥胖的进化起源现有假设的审查.
- 构建了元炎症假设的表述.
- 考虑宿主微生物组的遗传相互作用.
主要成果:
- 对病原体防御基因的强烈选择可能赋予了进化优势.
- 这些被选择的基因可能通过免疫能储能系统链接导致肥胖.
- 当包括肠道微生物群遗传学时,肥胖比以前认为的更加多基因.
结论:
- 超炎症假说为肥胖的进化根源提供了一个新的视角.
- 了解肥胖需要检查人类历史,人口遗传学和肠道微生物组.
- 一种多方面的方法对于揭示肥胖的复杂进化起源至关重要.
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