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Updated: Jun 5, 2025

In Vitro Analysis of E3 Ubiquitin Ligase Function
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通过其E1激活酶Uba4释放Urm1的氧化和释放的分子基础

Mikołaj Sokołowski1,2, Dominika Kwasna1, Keerthiraju E Ravichandran1,2

  • 1Malopolska Centre of Biotechnology (MCB), Jagiellonian University, Gronostajowa7a, 30-387 Krakow, Poland.

Nucleic acids research
|December 14, 2024
PubMed
概括

与乌比奎丁相关的修饰剂1 (Urm1) 被UBL蛋白激活剂4 (Uba4) 激活到酸的tRNAs. 这项研究揭示了Uba4/Urm1复杂结构和机制,澄清了Urm1激活及其在重要细胞通路中的作用.

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