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来自土耳其马拉蒂亚的四种土著杏仁品种的细胞毒性和亡潜力:全面评估

Ünzile Keleştemur¹, Sevgi Balcioğlu², Burhan Ateş³

¹Faculty of Health Sciences, Department of Occupational Health and Safety, Muş Alparslan University, Muş, Turkey.

Journal of food science

|December 14, 2024

概括

马拉蒂亚杏子,特别是卡巴阿斯品种提取物,显示出作为功能性食品的巨大潜力. 它们对癌症细胞系表现出强烈的细胞毒性和亡作用,抑制细胞增殖并诱导细胞死亡.

科学领域:

食品科学食品科学食品科学
生物化学生物化学
在瘤学瘤学.

背景情况:

功能性食品正因其健康益处而受到越来越多的关注,包括预防癌症.
马拉提亚大白具有具有治疗潜力的细胞毒性和亡性质.

研究的目的:

调查马拉蒂亚杏仁提取物对人类癌症细胞系 (MCF-7和Caco-2) 的细胞毒性和亡作用.
评估不同子品种,加工方法 (原料,成熟,干燥) 和提取溶剂 (甲醇,乙) 对这些影响的影响.

主要方法:

使用甲醇和酸盐提取四种马拉提亚杏子品种 (Hacıhaliloğlu,Hasanbey,Kabaaşı,Soğancı) 的原始,成熟和干燥形式.
细胞毒性和细胞亡测定包括MTT (3-(4,5-二甲基-2-thiazolyl) -2,5-二基-2H-四化物),伤口划伤,和酸/乙化物 (AO/EB) 染色.
总和黄含量的量测量.

主要成果:

来自干燥和生卡巴斯的乙提取物显示,与MCF-7 (48小时0.5毫克/毫升) 和Caco-2 (48小时1.95毫克/毫升) 细胞系相比,IC50值最低.
杏仁提取物在伤口划伤试验中显著抑制了癌细胞迁移 (10-30%的开口与对照中的70-80%相比).
AO/EB染色证实了由杏仁提取物诱导的细胞死亡和细胞亡的形态证据.

结论:

马拉蒂亚杏仁提取物,特别是来自Kabaaşı品种的提取物,对乳腺 (MCF-7) 和结肠 (Caco-2) 癌细胞具有强烈的细胞毒性和亡性.
这些发现凸显了马拉蒂亚杏仁作为癌症治疗的功能性食品成分的潜力.

关键词:

杏子是什么意思杏子是什么意思细胞毒性细胞毒性黄的总含量是什么?的总含量的总含量

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