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Updated: Jun 5, 2025

Author Spotlight: Unveiling the Role of SNF2L in Replication Fork Stability and Genome Duplication
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Published on: August 23, 2024

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在DNA断裂时,RPA和Rad27限制模板和倒置插入

Yang Yu1, Xin Wang2,3,4, Jordan Fox1

  • 1Baylor College of Medicine, Department of Molecular and Human Genetics, One Baylor Plaza, Houston, TX 77030, USA.

Nucleic acids research
|December 14, 2024
PubMed
概括

在DNA双链断裂 (DSB) 上的模板插入在癌症中很常见. 这项研究揭示了一种使用微同学学的折叠机制,涉及DNA聚合酶三角和末端连接通路,由RPA缺乏症加剧.

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