睡眠时间与低骨密度和骨质疏松症之间的关联:系统性审查和元分析
Junwei Tian1, Jianzeng Zhang1, Lu Ding2
1Department of Orthopaedic Surgery, The First Hospital of Jilin University, No. 71, Xinmin Street, Changchun, 130021, Jilin, China.
Calcified tissue international
|December 14, 2024
概括
长时间的睡眠时间与骨质疏松症的更高风险和较低的骨矿物质密度 (BMD) 有关. 睡眠时间短暂与骨质疏松症或骨质疏松症没有显著的关联,除了男性. 证据质量很低. 证据质量很低.
科学领域:
- 骨健康研究 骨健康研究
- 睡眠的药物 睡眠的药物
- 流行病学 流行病学
背景情况:
- 睡眠持续时间与各种不良健康结果有关.
- 睡眠时间和骨矿物质密度 (BMD) 或骨质疏松症之间的关系尚不清楚.
研究的目的:
- 系统地审查和分析有关短时间和长时间睡眠时间与骨质疏松/骨质疏松之间关系的证据.
- 在不同的人口群体 (男性,女性,绝经后女性,老年人) 中调查这些关联.
主要方法:
- 在主要数据库 (PubMed,Embase,CENTRAL,Web of Science,Scopus) 进行系统文献搜索,截至2024年7月15日.
- 对骨质疏松症调整的几率比率和 BMD 的线性回归系数的元分析.
- 对男性,女性,绝经后女性和老年人进行的子组分析.
主要成果:
- 长时间的睡眠时间与骨质疏松症的风险增加有关 (OR 1.19).
- 睡眠时间短暂与骨质疏松症没有显著的关联,除了男性.
- 长时间睡眠与 BMD 降低相关 (β-0.017),而短时间睡眠没有显著关联.
结论:
- 长时间的睡眠时间可能与骨质疏松症和骨硬化率降低有关,特别是在女性身上.
- 短睡眠与骨健康的关联是有限的,主要在男性中观察到.
- 目前的证据主要基于横截面研究,由于质量不佳,应谨慎解释.
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