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Updated: Jun 5, 2025

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention
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早期重症监护病房入院期间的药物基因组变异和镇静结果:一个务实的研究

Moataz E Mohamed1, Tam T Nguyen1, Jared Larson2

  • 1Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, USA.

Clinical and translational science
|December 14, 2024
PubMed
概括

药物基因组 (PGx) 变异没有显著影响机械通风 (MV) 关键病患者的镇静结果. 然而,患者对PGx测试表现出积极的看法,这表明了潜在的未来效用.

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Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
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Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
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