在男性婴儿中用于迷你青春期诱导的淋巴激素疗法,这些婴儿患有阴性淋巴激素的阴性淋巴症
Sophie Rhys-Evans1, Francesco d'Aniello1,2,3, Emma C Alexander4
1Centre for Endocrinology, William Harvey Research Institute, Queen Mary University of London, EC1M 6BQ London, UK.
The Journal of clinical endocrinology and metabolism
|December 14, 2024
概括
淋巴激素疗法有效地诱导男性婴儿的迷你青春期与先天性淋巴激素降低症 (CHH),改善阴茎的长度和丸下降. 这种治疗对生命早期的CHH管理有希望.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 生殖医学 生殖医学
- 遗传学 是一个遗传学.
背景情况:
- 先天性性性性 (CHH) 的特征是孤立的性素缺乏.
- 迷你青春期,一个短暂的下垂体-垂体-腺轴的产后激活,为婴儿中CHH诊断和治疗提供了一个关键的窗口.
- 目前男性婴儿的CHH治疗主要使用子大小的丸激素,但淋巴激素可能为丸发育提供额外的好处.
研究的目的:
- 系统地审查性腺激素治疗在被诊断为CHH的男婴中刺激迷你青春期相关结果的有效性.
- 评估性腺激素对阴茎长度,丸下降和迷你青春期期间激素标记物的影响.
主要方法:
- 根据PRISMA指南,对11个数据库进行了系统审查,使用Cochrane风险偏见工具评估证据质量.
- 包括11项涉及71名男婴的研究,包括那些患有卡尔曼综合征的研究.
- 数据综合结合了连续皮下输液和皮下注射性淋巴激素的结果.
主要成果:
- 在患有CHH的男性婴儿中,淋巴激素治疗导致阴茎长度和抑制B度的统计显著增加 (P = .0007).
- 在接受淋巴激素治疗的73%的患者中观察到部分或完全的丸下降.
- 治疗开始时的中位数年龄为4.2个月,随访时间为3至10年.
结论:
- 这一系统性审查提供了证据,支持淋巴激素在诱导CHH男性婴儿的迷你青春期结果中的有效性.
- 在这个人群中,淋巴激素治疗显示出促进丸下降和发育的潜力.
- 局限性包括数据的变化和不同的治疗方式,影响可靠性和通用性.
相关概念视频
Infertility in Males
242
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
242
Testosterone: Functions and Regulation
548
The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
548
Signs of Puberty
239
Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
239
Gonadal and Placental Hormones
1.3K
The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
1.3K
Development of the Sexual Organs in the Embryo and Fetus
535
Development of the reproductive organs in an embryo starts from a bipotential state. This means the early embryo can develop either male or female reproductive organs. The formation of these organs begins with the growth of gonadal ridges that arise from the intermediate mesoderm during the fifth week of development.
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the...
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the...
535
Hormonal Regulation of the Menstrual Cycle
289
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
289


