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在认知功能中NSUN2-介导的tRNA m5C安装的空间调节

Yulia Gonskikh1, Christian Tirrito2,3, Praneeth Bommisetti1

  • 1Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Nucleic acids research
|December 14, 2024
PubMed
概括

在NSUN2中智力障碍突变会损害tRNA5-甲基细胞素 (m5C) 修饰,影响认知功能. 减少tRNA结合,而不仅仅是局部化,解释了这种损伤,突出了m5C.

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