不良的葡萄糖代谢与功能性体质障碍有关. 一个基于一般人口的横截面研究:DanFunD研究
Thomas Meinertz Dantoft1, Sine Wanda Jørgensen2, Kaare Bro Wellnitz3
1Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Frederiksberg, Denmark.
功能性体力障碍 (FSD) 与不良的葡萄糖代谢有关,特别是胰岛素水平升高和胰岛素抵抗. 虽然血糖和HbA1c的关联存在,但它们可能受到生活方式因素的影响.
科学领域:
- 代谢健康及其与心理和体质条件的关系.
- 功能性体质疾病的流行病学和葡萄糖代谢标志物.
背景情况:
- 之前的研究表明,异常葡萄糖代谢标志物 (禁食葡萄糖,胰岛素,HbA1c,HOMA-IR) 和功能性体力障碍 (FSD) 之间存在联系.
- 在一般人群中对各种FSD定义进行系统分析是缺乏的.
研究的目的:
- 在一个基于人口的大样本中调查不良葡萄糖代谢和FSD之间的关联.
- 通过同时使用多个界限来检查FSD:慢性疲劳 (CF),慢性广泛疼痛 (CWP),易怒肠 (IB) 和身体痛苦综合征 (BDS).
主要方法:
- 在丹麦对8183名年龄在18-76岁之间的人进行了横截面,基于人口的研究.
- 通过自我管理的问卷测量FSD界限;BDS也通过亚样本的诊断面试来评估.
- 根据年龄,性别,生活方式和社会因素调整后勤回归模型.
主要成果:
- 最初的分析显示了所有FSD类型和葡萄糖,胰岛素和HbA1c (除IB和HbA1c) 之间的关联.
- 增加的胰岛素抵抗与所有BDS群体有关,并在男性中证实了BDS.
- 经过生活方式调整后,CF,多器官BDS和葡萄糖/HbA1c之间的关联仍然存在;CF,单器官BDS,多器官BDS和女性的整体BDS仍然与胰岛素抵抗有关.
结论:
- 功能性体质障碍与血胰岛素水平增加和胰岛素抵抗有关.
- 在FSD群体中血糖和HbA1c的升高可能归因于不健康的生活方式.
- 需要进一步的前性研究来澄清这些发现的临床意义.
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