半IPN水凝中阿加洛斯对持续释放的Polymyxin B的影响
David Filho1, Marcelo Guerrero1, Ricardo Castro2
1Laboratory of Bio & Nano Materials, Drug Delivery and Controlled Release, Department of Microbiology, Faculty of Health Sciences, University of Talca, Talca, Chile; PhD Program in Science, R&D Bioactive Products Department, Chemistry Institute of Natural Resources, University of Talca, Talca, Chile.
Colloids and surfaces. B, Biointerfaces
|December 14, 2024
概括
这项研究开发了阿加罗斯修饰的水凝,用于持续的药物输送. 更高的阿加罗斯含量导致药物释放速度更慢,显示出长期感染治疗和伤口愈合应用的潜力.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 药物输送系统 药物输送系统
背景情况:
- 水凝 (HGs) 是具有高含水量的3D聚合物网络,适合生物医学应用.
- 半互穿透的聚合物网络 (Semi-IPNs) 为先进的材料设计提供可调节的特性.
研究的目的:
- 调查将阿加洛斯 (AGA) 纳入聚烯酸 (p) (AA) /N,N'-甲二烯酸 (p) (亚克利胺) (MBA) 半IPN对波利米辛B (PolB) 持续释放的影响.
- 评估这些新型水凝的结构性,热性,膨胀性,机械性和药物释放性.
主要方法:
- 半IPN水凝通过自由基聚合合成,具有不同的AGA度.
- 鉴定涉及FTIR,SEM,TGA和DSC. 这三种类型的特征.
- 在生理条件下评估了胀行为,机械强度和Polymyxin B释放动力学.
主要成果:
- 糖的加入增强了水凝的机械强度,胀和药物保留.
- 较高的AGA度导致了较慢和更持续的Polymyxin B释放概况.
- 开发的水凝显示出对Pseudomonas aeruginosa的持续抗菌活性,以及与NIH-3T3纤维细胞的良好生物相容性.
结论:
- 糖修饰的半IPN水凝对持续的药物输送具有有前途的特性.
- 这些水凝适用于长期的治疗应用,包括感染治疗和伤口愈合.
- 这些水凝的调节性使得它们适用于各种生物医学应用.
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