慢性子宫内膜炎和生育能力:一个由微生物联系在一起的二项式
Rocío Sánchez-Ruiz1, Itahisa Hernández-Chico2, Bárbara Lara-Del-Río3
1Department of Gynecology and Obstetrics, Hospital Universitario Virgen de las Nieves-ibs, 18014 Granada, Spain.
European journal of obstetrics, gynecology, and reproductive biology
|December 14, 2024
概括
慢性子宫内膜炎与子宫内膜微生物群的改变有关,在受影响的女性中发现的Lactobacillus物种较少,Gardnerella vaginalis较多. 这种微生物转移会影响生育能力,需要进一步研究以获得更好的治疗策略.
科学领域:
- 生殖医学 生殖医学
- 微生物学 微生物学
- 妇科 妇科 妇科 妇科
背景情况:
- 慢性子宫内膜炎 (CE) 是子宫内膜的持续性炎症,通常与不孕症有关.
- 人们越来越认识到子宫内膜微生物群在CE病变发生中的作用.
- 了解CE中的微生物转变对于改善生殖结果至关重要.
研究的目的:
- 研究特定微生物和慢性子宫内膜炎之间的关系.
- 将当地发现与关于子宫内膜微生物群和CE的现有文献进行比较.
- 在接受生育治疗的妇女中识别与CE相关的微生物模式.
主要方法:
- 对因生育问题 (2021-2022) 接受治疗的女性进行110次子宫内膜活检的回顾性描述性研究.
- 在被诊断患有和没有慢性子宫内膜炎的妇女之间比较微生物发现.
- 对微生物流行率的分析,重点关注Lactobacillus spp. 和其他常见的细菌.
主要成果:
- 慢性子宫内膜炎在50.91%的女性中被诊断出.
- 除 Lactobacillus spp. 之外的其他微生物 在患有CE的女性中明显更为普遍 (p=0.009).
- Gardnerella vaginalis是最常见的非乳杆菌分离物 (10.71%),其次是链球菌物种和Corynebacterium amycolatum.
结论:
- 子宫内膜微生物群的组成在具有和没有CE的女性之间有显著差异.
- 有较少的Lactobacillus spp. 的比例. 和加德内瑞拉种类的比例增加. 标志着CE的特征.
- 需要进一步的研究来阐明微生物在CE中的作用,以获得治疗指导和改善生殖预后.
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