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CTLA-4 rs5742909但不是ADAM33 rs2280091是COVID-19死亡率的一个预测因素

Farzaneh Sheikhian¹, Mohammad Mehdi Golparvar², Iraj Ahmadi³

¹Department of Biology, Varamin-Pishva Branch, Islamic Azad University, Varamin, Iran.

Journal of infection and public health

|December 14, 2024

概括

细胞毒性T淋巴细胞相关抗原-4 (CTLA-4) rs5742909单核酸多态 (SNP) 与增加COVID-19死亡风险有关. 分解蛋白和金属蛋白酶33 (ADAM33) rs2280091 SNPs显示了与COVID-19死亡率的变体特定关联.

科学领域:

遗传学遗传学是一个
免疫学免疫学免疫学
病毒学病毒学

背景情况:

单核酸多态 (SNP) 与COVID-19易感性有关.
细胞毒性T淋巴细胞相关抗原-4 (CTLA-4) 影响病毒感染的进展.
分解蛋白和金属蛋白酶33 (ADAM33) 基因对喘和呼吸道反应有影响.

研究的目的:

为了调查CTLA-4 rs5742909和ADAM33 rs2280091SNP与COVID-19死亡之间的联系.
为了分析不同严重急性呼吸综合征冠状病毒2 (SARS-CoV-2) 变种之间的这些关联.

主要方法:

使用PCR-RFLP进行CTLA-4 rs5742909和ADAM33 rs2280091SNP的基因型鉴定.
研究包括1734名康复和1450名已死亡的COVID-19患者.

主要成果:

CTLA-4 rs5742909 C/T-T/T基因型与三种SARS-CoV-2变种中较高的COVID-19死亡率显著相关.
ADAM33 rs2280091显示,与COVID-19死亡率没有整体显著的关联.
ADAM33 rs2280091 GA基因型与感染Delta变种的个体的死亡率有关.

结论:

CTLA-4 rs5742909 作为预测COVID-19严重程度的潜在标志物.
使用ADAM33 rs2280091的预后取决于涉及的特定SARS-CoV-2变种.

关键词:

在 ADAM3333 中,在 CTLA-4 中.新冠病毒疾病2019年严重急性呼吸系统综合征冠状病毒2种变体

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