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人工消化是研究胃肠道中纳米塑料命运的最坏情况

Giselle Lee¹, Ya-Jhu Jhang², Yu-Tung Jhang³

¹School of Food Safety, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan.

Journal of hazardous materials

|December 14, 2024

概括

纳米塑料 (NPls) 的摄入带来风险. 这项研究表明,体外消化模型预测了NPls在肠道中的聚合,考虑到pH和蛋白相互作用等因素,这对于风险评估至关重要.

科学领域:

环境科学环境科学
毒理学毒理学毒理学
材料科学材料科学材料科学

背景情况:

人类通过摄入暴露于纳米塑料 (NPls) 是不可避免的.
了解消化过程中的NPl行为对于准确的风险评估至关重要.
NPl的大小影响吸收效率和生物相互作用.

研究的目的:

在体外消化过程中描述聚钢 (PS) 和胺-甲树脂 (MF) 纳米塑料的行为和聚合状态.
为了评估食物矩阵,pH和蛋白质冠状体对NPls聚合物的影响.
将体外消化结果与使用人类和猪消化液获得的结果进行比较.

主要方法:

在体外消化模型模拟胃肠道条件.
使用各种技术对光PS和MFNPls进行表征.
分析带有或没有食品矩阵和pH调整的NPls.
人工消化液结果与真实的人类和猪消化液的比较.

主要成果:

不同的NPl类型和电荷表现出不同的聚合状态.
较小的PS颗粒对pH和蛋白质冠状体对聚合的影响更敏感.
食物矩阵没有显著改变颗粒大小,但改变了蛋白质冠状组成.
在体外消化准确预测了在真实消化液中观察到的NPls聚合趋势,尽管被低估了.

结论:

在体外消化作为一个保守的模型来预测纳米塑料聚合在胃肠道.
pH 和蛋白质冠状体显著影响NPls的行为,特别是对于较小的粒子.
这项研究为人类纳米塑料风险评估提供了宝贵的见解.

关键词:

在体外消化过程中消化.纳米追踪分析分析的方法纳米塑料是一种纳米塑料.猪的消化液是猪的消化液.蛋白质冠状病毒的冠状病毒

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