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Updated: Jul 25, 2026

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高通量单细胞代谢物分析显示,代谢重编程在肺癌中赋予西斯胺耐药性

Changyi Liu1, Siyuan Pan2, Xingyu Pan2

  • 1State Key Laboratory of Complex, Severe, and Rare Diseases, Peking Union Medical College Hospital, Beijing, 100730, PR China.

Talanta
|December 14, 2024
PubMed
概括

研究人员开发了一种新的方法来研究细胞相互作用,并发现酸丁胆与肺癌药物耐药性有关. 这有助于了解癌细胞如何共享抗药性,为克服治疗挑战提供了洞察力.

关键词:
细胞对细胞的相互作用.西斯普拉丁的耐药性肺癌是一种肺癌.代谢重编程是一种代谢重编程.一个单细胞分析.

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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...