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在治疗头恶性瘤的质子疗法治疗儿科患者的骨髓缩症

Adam J Grippin¹, Andrew Kim², Yufei Liu³

¹Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

International journal of radiation oncology, biology, physics

|December 14, 2024

概括

骨质放射性死 (ORN) 在接受质子疗法 (PT) 治疗的儿科头癌患者中很罕见,只有1.7%的人患有ORN. 对骨的高剂量辐射与ORN的发展有关.

科学领域:

在瘤学瘤学.
辐射瘤学辐射瘤学
儿科瘤学儿科瘤学

背景情况:

骨质放射性死 (ORN) 是头 (H/N) 癌症的放射治疗后的一个重要并发症.
在接受H/N辐射的儿科患者中,ORN的发病率和特定风险因素尚未得到充分确定.

研究的目的:

为了确定ORN的发病率在治疗H/N恶性瘤的质子疗法 (PT) 的儿童.
为了确定与ORN发展相关的放射治疗相关的风险因素,在这个儿科队列.

主要方法:

对从单一机构收集的前性数据 (2006年12月 - 2020年2月) 的回顾性分析.
包括117名为H/N恶性瘤治疗PT的儿科患者.
对人口统计,瘤,治疗细节,ORN发生率和剂量计数据的审查.

主要成果:

该研究确定了117名患有H/N恶性瘤的儿科患者,他们接受了PT治疗.
最常见的是肌肉瘤 (46%) 和脑膜周围 (44%) 部位.
只有2名患者 (1.7%) 患有ORN,这两位患者都先前接受了牙科治疗,并对受影响的骨进行了高剂量的辐射 (最大剂量为68 Gy和64.2 Gy).

结论:

在为H/N恶性瘤接受PT的儿科患者中,ORN不常见.
在这个队列中,ORN的发病率为1.7%.

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