主体微生物群在代谢中的相互作用:对宿主葡萄糖稳态的影响
Dinakaran Vasudevan1, Buvaneswari Gajendhran2, Krishnan Swaminathan2
1Chemomicrobiomics Laboratory, Department of Biochemistry and Microbiology, KMCH Research Foundation, Coimbatore, 641 014, Tamil Nadu, India; Gut Microbiome Division, SKAN Research Trust, Bengaluru, 560 034, Karnataka, India.
Chemico-biological interactions
|December 14, 2024
概括
暴露影响全球数以百万计的人,导致糖尿病. 了解微生物与的相互作用是减轻健康风险和改善代谢疾病结果的关键.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 微生物学 微生物学
- 代谢疾病 代谢疾病
背景情况:
- (As) 是一个全球性的健康问题,被世界卫生组织确定为最大的大规模中毒,影响约2亿人.
- 暴露是代谢性疾病的重要危险因素,特别是糖尿病,通过破坏细胞功能,包括胰腺小岛细胞.
- 与其他重金属不同,由各种有机体代谢,包括微生物,植物和动物,影响其环境命运和生物影响.
研究的目的:
- 审查微生物与的相互作用及其在宿主暴露和健康风险中的作用.
- 提供关于人体及其微生物群的代谢的见解.
- 探索将物种与糖尿病病因联系起来的分子途径,并讨论缓解策略.
主要方法:
- 关于代谢和微生物与相互作用的现有研究的文献综述.
- 对对葡萄糖平衡和糖尿病的影响背后的分子机制的分析.
- 讨论目前的局限性和毒解毒和转化医学的未来前景.
主要成果:
- 微生物与的相互作用显著影响宿主暴露和相关的健康风险.
- 人类微生物群的代谢在调节其毒性和对代谢途径的影响方面发挥着至关重要的作用.
- 特定的分子通路将暴露与胰岛素分泌受损和糖尿病的发展联系起来.
结论:
- 了解代谢,宿主微生物群动态和葡萄糖平衡之间的复杂相互作用对于解决相关代谢疾病至关重要.
- 需要进一步的研究,以制定有效的策略,在翻译医学中减轻和排毒.
- 向微生物与的相互作用为管理引起的糖尿病和其他代谢障碍提供了潜在的治疗途径.
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