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意识障碍中的异常特征:休息状态功能磁共振成像研究

Hui Li¹, Linghui Dong¹, Jiajie Liu²

¹Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China; China Rehabilitation Research Center, Beijing, China; University of Health and Rehabilitation Sciences, Qingdao, Shandong, China.

|December 14, 2024

概括

功能性脑成像揭示了意识障碍 (DoC) 中不同的模式. 休息状态fMRI显示,与健康对照组 (HC) 相比,在最小意识状态 (MCS) 和植物状态 (VS) 患者中,大脑功能发生变化.

科学领域:

神经科学是一个神经科学.
临床神经学临床神经学
医疗成像医学成像

背景情况:

意识障碍 (DoC) 存在诊断方面的挑战.
对意识水平的客观评估对于患者的护理和预后至关重要.
休息状态功能磁共振成像 (rs-fMRI) 提供了对大脑网络功能的洞察.

研究的目的:

调查DoC患者的功能性脑成像特征.
使用神经成像标记,区分最小意识状态 (MCS),植物状态 (VS) 和健康对照 (HC).
探索DoC的静态和动态功能连接变化.

主要方法:

前性队列研究包括27名MCS,23名VS患者和25名健康对照 (HC).
rs-fMRI用于评估低频波动幅度 (ALFF),区域同质性 (ReHo),中心度 (DC) 和功能连接性 (FC).
动态FC (dFC) 使用滑动窗口方法进行分析;统计分析包括ROC和Pearson相关性.

主要成果:

与HC相比,MCS和VS组显示ALFF,ReHo和DC降低,FC降低.
与MCS患者相比,VS患者在特定的大脑区域的值较低.
在各组中观察到静态和动态FC的显著差异,特别是在皮质-状皮质-甲状腺-甲状腺-皮质中介电路内.
变化与昏迷恢复量表修订 (CRS-R) 相对应,并实现了高分类准确性 (AUC > 0.8).

结论:

患有DoC的患者表现出异常的静态和动态大脑功能模式.
rs-fMRI的变化与DoC的意识水平密切相关.
神经成像标记有潜力对意识水平进行客观评估和差异化.

关键词:

意识的障碍意识的障碍最少意识的状态最少意识的状态.静止状态功能磁共振成像技术植物状态植物状态

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