运动训练改变了老年人休息时脑衍生的神经营养因子度:随机对照试验的系统综述与元分析
Farhad Gholami1, Javad Mesrabadi2, Mohadeseh Iranpour1
1Department of Physical Education and Sport Sciences, Faculty of Physical Education, Shahrood University of Technology, Shahrood, Semnan, Iran.
Experimental gerontology
|December 14, 2024
概括
在老年人中,运动训练显著提高了来自大脑的神经营养因子 (BDNF) 的水平. 这种蛋白质对大脑健康至关重要,这表明运动可能会对抗与年龄相关的神经退行.
科学领域:
- 神经科学和运动生理学
- 老年学和衰老研究研究.
背景情况:
- 大脑衍生神经营养因子 (BDNF) 在神经元可塑性,学习和记忆中起着至关重要的作用.
- 衰老通常与BDNF水平的下降有关,可能导致认知障碍和神经退行性疾病.
研究的目的:
- 系统地审查和元分析运动训练对老年人休息BDNF水平的影响.
- 确定不同运动方式,持续时间,强度和频率对BDNF水平的影响.
主要方法:
- 进行了随机对照试验 (RCT) 的系统审查和元分析.
- 在PubMed,Web of Science和Scopus进行了至少4周研究的搜索.
- 使用随机效应模型计算标准化平均差异 (SMD).
主要成果:
- 35个RCT符合纳入标准,显示BDNF静止水平的总体显著增加 (SMD=0.56).
- 运动训练在血 (SMD = 0.63) 和血清 (SMD = 0.54) 中都增加了BDNF.
- 有氧,抵抗和综合训练都增加了BDNF,持续时间较长 (≥12周),强度中等至强烈/强烈,每周3-4次训练显示出最大的影响.
结论:
- 运动训练是提高老年人BDNF水平的有效干预措施.
- 定期体育活动,特别是中等至强烈的强度和足够的持续时间,可能是支持大脑健康和减轻与年龄相关的神经退行症的关键策略.
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