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Updated: Jun 5, 2025

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氧化CaMKIIα半氨酸抑制了由酸化诱导的自主激活

Nathália Rocco-Machado1, Max Deng1, Yi He2

  • 1Laboratory of Biochemistry, National Heart, Lung and Blood Institute, Maryland, USA.

Archives of biochemistry and biophysics
|December 14, 2024
PubMed
概括

阿尔茨海默病通过囊氧化损害了CaMKIIα的功能,形成了阻断Thr286酸化的二硫化键. 这种二硫化物形成减少了CaMKIIα的自主激活,导致突触功能障碍.

关键词:
卡姆基尔是什么意思 卡姆基尔半氨酸 (cysteine) 是一种蛋白质.硫化二氧化物是二硫化物.氧化应激是一种氧化应激.雷多克斯调节法规的规定

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