基于水凝的色度测量节能传感器,用于现场检测汗水中的化物离子和葡萄糖
Yu-Ting Tai1, Cheng-Yu Wei2, Fu-Hsiang Ko1
1Department of Materials Science and Engineering, National Yang Ming Chiao Tung University, 1001 University Road, Hsinchu, 30010, Taiwan.
Biosensors & bioelectronics
|December 15, 2024
概括
一个新的水凝传感器可以检测出汗中的囊性纤维化和糖尿病标志物. 这种非侵入性诊断工具使用细菌纤维素,碳氧甲基纤维素和酸盐进行准确的实时健康监测.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 分析化学 分析化学
背景情况:
- 非侵入性诊断对于健康监测和疾病检测至关重要.
- 汗液分析为确定临床生物标志物提供了一个有希望的途径.
- 现有的方法可能缺乏广泛使用的灵敏度或方便性.
研究的目的:
- 开发一种新的基于水凝的色度传感器,用于汗水分析.
- 允许对囊性纤维化和糖尿病的关键生物标志物的非侵入性检测.
- 使用低功耗,电池驱动的设备进行实时诊断.
主要方法:
- 使用细菌纤维素 (BC),碳氧甲基纤维素 (CMC) 和奇托 (Ch) 制造水凝传感器.
- 将水凝与可重复使用的基于聚二甲基西洛的微流体装置集成.
- 材料属性的评估,包括拉伸强度和吸汗能力.
- 在汗水中测定化物离子 (Cl-) 和葡萄糖度的色度测定.
主要成果:
- 含有0.6%Ch的BC-CMC水凝对吸汗和生物标志物测量表现出最佳的特性.
- 传感器表现出线性 Cl- 检测响应 (限值为 0.56 mM,范围为 20-100 mM),适用于囊性纤维化诊断.
- 传感器显示了葡萄糖检测的线性响应 (极限0.1μM,范围6.25-500μM),适用于糖尿病诊断.
- 在特定的存储条件下,传感器在一个月内保持稳定.
结论:
- 开发的水凝传感器为非侵入性汗水分析提供了一个敏感和选择性的平台.
- 这项技术具有实时诊断囊性纤维化和糖尿病的巨大潜力.
- 传感器的稳定性和易用性支持其临床适用性.
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