怀孕不良结果与认知障碍和痴呆症之间的关联:系统性审查和元分析
Eliza C Miller1, Patrick Conley2, Mohammad Alirezaei3
1Department of Neurology, Columbia University, New York, NY, USA.
The lancet. Healthy longevity
|December 15, 2024
概括
怀孕不良后果会增加女性痴呆症的风险. 怀孕前史有不良结果的妇女应对认知能力下降进行监测,并评估其他风险因素.
科学领域:
- 神经学 神经学
- 产科 产科 产科 产科 产科
- 流行病学 流行病学
背景情况:
- 怀孕不良后果与增加脑血管疾病风险有关.
- 怀孕不良结果与认知障碍/痴呆症之间的关联不太清楚.
- 这项研究综合了关于孕妇不良妊娠结果和轻度认知障碍/痴呆症的数据.
研究的目的:
- 系统地审查和元分析关于不良妊娠结果和认知障碍/痴呆症的数据.
- 评估特定不良妊娠结果与痴呆症亚型之间的关联.
主要方法:
- 观察性研究和临床试验的系统审查和元分析.
- 在PubMed,科学网和Embase搜索到2024年7月18日.
- 包括报告怀孕不良结果的女性轻度认知障碍或痴呆症的研究;不包括先前存在的疾病和产后早期认知障碍.
主要成果:
- 15项研究 (7,347,202名参与者) 符合纳入标准;11项 (6,263,431名参与者) 进行了元分析.
- 任何与所有原因痴呆症 (aHR 1.32),阿尔茨海默病 (aHR 1.26) 和血管痴呆症 (aHR 1.94) 的风险增加相关的不良妊娠结果.
- 怀孕的高血压疾病与所有原因 (aHR 1.32) 和血管痴呆症 (aHR 1.78) 相关;死胎与所有原因痴呆症没有显著的关联.
结论:
- 怀孕后不良后果的女性患痴呆症的风险较高.
- 建议对其他痴呆风险因素进行评估,并密切监测认知能力下降.
- 未来的研究应该利用对暴露和结果的前性,客观措施.
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