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轻度炎症性肠病的患病率和预后:基于人口的队列研究,1997-2020年
Henrik Albaek Jacobsen1, Anastasia Karachalia-Sandri2, Anthony C Ebert2
1Center for Molecular Prediction of Inflammatory Bowel Disease, PREDICT, Department of Clinical Medicine, Aalborg University, Copenhagen, Denmark; Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark.
大约四分之一的轻度性结肠炎 (UC) 患者和一半的轻度克罗恩病 (CD) 患者进展到中度至重度的疾病. 诊断时年轻的年龄增加了炎症性肠病 (IBD) 的进展风险.
科学领域:
- 胃肠病学 胃肠病学
- 临床流行病学临床流行病学
- 炎症性肠道疾病研究研究
背景情况:
- 炎症性肠道疾病 (IBD),包括性结肠炎 (UC) 和克罗恩病 (CD),是具有不同严重程度的复杂疾病.
- 了解轻度IBD的自然史和进展对于有效的患者管理至关重要.
研究的目的:
- 为了确定轻度IBD的患病率和预后在未经选择的,基于人口的队列.
- 描述从轻度到中度至重度IBD进展的速度和预测因素.
主要方法:
- 分析了4607名IBD患者的基于人口的队列,这些患者在1997-2020年期间在北丹麦被诊断出IBD.
- 轻度疾病是由初始治疗定义的;进展是由包括先进疗法,住院或手术在内的复合结果决定的.
- 时间到事件分析被用来评估基于IBD亚型,年龄,性别和疾病持续时间的进展概率.
主要成果:
- 在2315名初始轻度IBD患者中,24.5%的UC和46%的CD进展为中度至重度疾病.
- 总的来说,52.3%的UC和86.8%的CD患者在随访期间进展.
- 诊断时的年龄较小 (<18岁) 与进展的可能性更高有关.
结论:
- 很大一部分患有轻度UC的患者 (约. 25%) 和轻度CD (大约. 50%) 随着时间的推移而发展为更严重的疾病.
- 在诊断时年轻的患者中,进展风险更高.
- 轻度疾病持续时间较长似乎会降低疾病进展的可能性.
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