来自不同受孕方法的兄弟姐妹的周产期结果:用自身卵子或捐赠卵子进行体外受精与无助医学受孕相比
Hila Shalev-Ram1, Anat Hershko Klement2, Einat Haikin-Herzberger1
1IVF Unit, Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba, Israel; School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Fertility and sterility
|December 15, 2024
概括
使用女性自己的卵子进行体外受精 (IVF) 增加了早产和妊娠年龄小的风险. 捐赠卵子怀孕没有显示出这些结果的风险增加,但对于妊娠年龄来说,大胎儿的发育率更高.
科学领域:
- 生殖医学 生殖医学
- 围产期流行病学 围产期流行病学
- 产科 产科 产科 产科 产科
背景情况:
- 像体外受精 (IVF) 这样的辅助生殖技术 (ART) 越来越多地用于怀孕.
- 了解与不同ART方法相关的围产期结果对于患者咨询和护理至关重要.
- 兄弟分析在比较受孕方法时提供了一种独特的方法来控制遗传和环境因素.
研究的目的:
- 为了在兄弟姐妹分析框架内比较通过自主体IVF,捐赠卵子IVF和自然受孕的怀孕之间的周产期结果.
- 调查怀孕方法与早产 (PTB) 和怀孕年龄小 (SGA) 的风险之间的关联.
主要方法:
- 从2000年至2018年使用电子病历的回顾性队列研究.
- 包括两次怀孕的母亲:A队列 (无辅助与无辅助+自主试管婴儿),B队列 (无辅助与无辅助+捐赠卵子试管婴儿).
- 结果比较包括PTB (<37周),SGA,低出生体重,非常低出生体重和LGA.
主要成果:
- 自主试管婴儿怀孕显示PTB (12%对3.5%) 和SGA比无辅助怀孕的比率显著更高 (PTB的调整OR:3.32,SGA:1.88).
- 与无辅助怀孕相比,捐赠卵子怀孕没有显示PTB或SGA的增加率.
- 捐赠卵子怀孕的LGA发病率较高 (24%对16.5%).
结论:
- 使用自身卵子进行体外受精与PTB和SGA的风险增加有关.
- 捐赠卵子怀孕似乎具有与无助怀孕相似的PTB和SGA风险.
- 捐赠卵子怀孕与较高的LGA发病率有关.
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